DENVER -- Even when the San Francisco Giants pick up a rare win at Coors Field, they still lose. . In this case, two pitchers -- starter Matt Cain and reliever Santiago Casilla, who both strained their right hamstrings and will undergo MRIs to determine the severity. Hunter Pence hit one of San Franciscos three solo homers and reliever Yusmeiro Petit threw three sharp innings after Cain left as the Giants beat the Colorado Rockies 5-1 on Wednesday night. "The win was great," Pence said, "but its a huge blow to lose Cain and Casilla." Pablo Sandoval and Brandon Crawford also connected for the NL West-leading Giants, who won at this hitter friendly venue for just the fifth time in 15 games dating back to last season. Cain had good command and was cruising along, not allowing a hit through three innings. Then, on his last pitch of the third, he felt a twinge in his hamstring. Casilla was hurt in the ninth inning when he tried to beat out an infield hit, falling over the bag and rolling several times on the field. He was helped to the dugout by the trainers and was replaced on the mound by Jeremy Affeldt, who finished the game. To think, just moments before in the dugout, Giants manager Bruce Bochy told Casilla to not even bother swinging -- just take it easy at the plate. "I was shocked he was running like that," Bochy said. "Guess he thought he had a hit. I dont know what got into him. Never seen him run like that." Petit (3-1) pitched effectively in Cains place as he and four other relievers limited the best offensive team in the majors to just five hits. Jhoulys Chacin (0-3) worked 5 2-3 innings and allowed three runs, including a homer to Pence in the fourth and another to Sandoval two innings later. "Two bad pitches, two homers, two runs," Chacin said. "I pitched good. We lost and thats all I care about." Crawford added a solo shot off Matt Belisle in the seventh as the Giants took the middle contest to even the three-game series. The Rockies have yet to lose a series at home this year. Trailing 5-0 in the eighth, the Rockies loaded the bases with no outs. Michael Cuddyer sent a grounder up the middle that Crawford tracked down and scooped over to second base with his glove to start a double play. Troy Tulowitzki then flew out limit the damage to only a run. Cain was settling into a rhythm when Rockies second baseman D.J. LeMahieu sent a sharp comebacker at the right-hander in the third. While the ball glanced off Cains glove, the Giants came out to check on him. Cain said after the game that had nothing to do with his hamstring injury. Earlier this season, Cain missed 13 games after he cut his right index finger while making a ham-and-cheese sandwich in the Giants clubhouse. The cut didnt require stitches. Optimistic this injury will heal fast? "Well see how tomorrow it feels," Cain said. "Still got some adrenaline going. But its calming down." Carlos Gonzalez also was banged up as he left the game as part of a double-switch in the eighth because of inflammation in his left index finger. He said he had an X-ray during the game and its not broken. "One of those things I have to deal with and get treatment every day," the slugger said. Tulowitzkis torrid hitting at home this season (.521 with eight homers) caught the attention of Giants broadcaster and former major league pitcher Mike Krukow. "Youre always skeptical -- its just the way you are as a player," Krukow said before the game. "Hes hitting as if hes getting signs. Im not accusing anybody of anything." Still, Rockies manager Walt Weiss had some fun with the assertion his shortstop is somehow stealing signs. "We have a light bulb on the scoreboard we flash. Keep an eye on Dinger (the teams mascot), hes involved," Weiss said. "We switch out the balls. Got the umpires in on it. "I love it when other teams talk about that," Weiss said. "I think its great. I think it feeds the beast." NOTES: Bochy said Buster Posey (nerve irritation in lower back) is "doing a lot better" and the catcher could be in the lineup Thursday. ... RHP Tim Hudson (4-2) will take the mound in the series finale on Thursday. The Rockies will throw LHP Jorge De La Rosa (5-3). . Scrivens stopped 48 shots and captain Andrew Ference scored in overtime as the Oilers pulled off a 4-3 upset of the Anaheim Ducks on Friday. . He has spent much of his adult life trying to give back to his native South Sudan, the war-torn African nation the Cavaliers forward and his family fled when he was a young boy.EASTBOURNE, England -- Victoria Azarenka was reasonably satisfied after losing her first match in more than three months, a three-setter in the first round of the Aegon Championships on Tuesday. Azarenka, the former No. 1 recovered from a left foot injury, lost 4-6, 6-3, 7-5 to Camila Giorgi of Italy after 2 hours, 46 minutes. "Thats exactly what I wanted," Azarenka said. "I wanted to have a competitive match. I wanted to test myself, to play for a long time, see how my body is going to react. "Im pretty pleased with what happened. Obviously the result is the result, but thats a beginning. Its a starting point. There are a lot of positive things that I can take from what happened today." Third seed Jelena Jankovic of Serbia was also beaten, going down 6-3, 6-3 against American Madison Keys, and second seed Petra Kvitova also struggled before beating fellow Czech Lucie Safarova 6-1, 5-7, 7-6 (4), winning the last five points to claim victory on her third match point. Giorgi had previously demonstrated her grass-court skills by reaching the fourth round at Wimbledon as a qualifier in 2012, aand she was a third-round finisher last year. . Azarenka won the first set from 4-2 down. Giorgi took a 5-0 lead in the second, saving five break points at 4-0. In the final set, Giorgi failed to serve out the match at 5-4, but broke again at 6-5 when Azarenka netted a backhand, and closed out the match at her second opportunity. Despite her defeat, Azarenka believed she was almost ready to compete again at the highest level. "I was really happy that I was there for every single moment, for every single ball," she said. "I felt that my level of concentration was really high. I just have to get into that rhythm." In other matches, former champion Ekaterina Makarova defeated Italian qualifier Francesca Schiavone 7-5, 6-3, and seventh-seeded Italian Sara Errani was beaten 7-6 (5), 6-2 by American qualifier Lauren Davis. There were also wins for sixth seed Flavia Pennetta, Slovak Daniela Hantuchova, Britains Johanna Konta and American Varvara Lepchenko. In the ATP event, seventh seed Santiago Giraldo of Colombia was beaten 6-3, 6-7 (5), 6-3 by Jarkko Nieminen of Finland. ' ' '